PUBLICATIONS
Academic Publications
Independent Research at Queens College - CUNY
Coming Soon !!!!
Prior to Queens College - CUNY
1. Rita Fuerst, Jun Yong Choi, Anna M. Knapinska, Lyndsay Smith, Michael D. Cameron, Claudia H. Ruiz, Gregg B. Fields, and William R. Roush,
Development of MMP-13 inhibitors with optimized pharmacokinetic properties: A structure-activity/ structure-property relationship study, Bioorg. Med. Chem., 2018, 26 (18), 4984-4995
2. Claudia Magalhaes Calvet, Jun Yong Choi, Diane Thomas, Brian Suzuki, Ken Hirata, Sharon Johnson, Jiri Gut, Liliane Batista de Mesquita,
Alanderson Nogueira, Marcelo Meuser, Tatiana Araujo Silva, Jair Lage Siqueira-Neto, William R. Roush, Mirian Claudia de Souza Pereira,
James H. McKerrow, and Larissa M. Podust, 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a
chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection, PLoS Negl. Trop. Dis., 2017, 11(12): e0006132
3. Spencer D. Wood, Wayne Grant, Isabel M. Adrados, Jun Yong Choi, Derek R. Ducket, William R. Roush, In Silico High-throughput Screening To
Identify Indazole-Derived ULK1 Inhibitors, ACS Med. Chem. Lett., 2017, 8 (12) 1258-1263
4. Jun Yong Choi, Rita Fuerst, Anna Knapinska, P. John Hart, Gregg B. Fields, and William R. Roush, Comparative structural analysis and
molecular design for the development of highly potent and selective agents targeting Matrix Metalloproteinase 13, J. Med. Chem., 2017, 60, 5816-
5825 (highlighted in Faculty of 1000)
5. Jun Yong Choi, and Rita Fuerst, Virtual High-throughput Screening for Matrix Metalloproteinase Inhibitors, Methods. Mol. Biol., 2017, 1579, 259
271
6. Jun Yong Choi, and William R. Roush, Structure Based Design of CYP51 Inhibitors, Curr. Top. in Med. Chem., 2017, 17, 30-39
7. Laura-Isobel McCall, Amale El Aroussi, Jun Yong Choi, Geraldine De Muylder, Jonathan Johnston, Steven Chen, William R. Roush, Larissa M.
Podust, and James H. McKerrow, Targeting ergosterol biosynthesis in Leishmania donovani: essentiality of lanosterol 14α-demethylase, PLoS
Negl.Trop. Dis., 2015, 9, e0003588
8. Debora F. Vieira, Jun Yong Choi, Claudia M. Calvet, Jair Lage Siqueira-Neto, Jonathan B. Johnston, Danielle Kellar, Jiri Gut, Michael D. Cameron,
James H. McKerrow, William R. Roush, and Larissa M. Podust, Binding mode and potency of N-indolyl-oxopyridinyl-4-amino-propanyl-based
inhibitors targeting Trypanosoma cruzi CYP51, J. Med. Chem., 2014, 57, 10162-10175
9. Timothy P. Spicer, Jianwen Jiang, Alexander B. Taylor, Jun Yong Choi, P. John Hart, William R. Roush, Gregg B. Fields, Peter S. Hodder, and
Dmitriy Minond, Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in
vitro, J. Med. Chem., 2014, 57, 9598-9611
10. Jun Yong Choi, Larissa M. Podust, and William R. Roush, Drug strategies targeting CYP51 in neglected tropical diseases, Chem. Rev., 2014,
114, 11242-11271
11. Claudia M. Calvet, Debora F. Vieira, Jun Yong Choi, Danielle Kellar, Michael D. Cameron, Jair Lage Siqueira-Neto, Jiri Gut, Li Lin, Susan Khan,
James H. McKerrow, William R. Roush, and Larissa M. Podust, 4-aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with
improved pharmacokinetic profile and in vivo potency, J. Med. Chem., 2014, 57, 6989-7005
12. Debora F. Vieira, Jun Yong Choi, William R. Roush, and Larissa M. Podust, Expanding the binding envelope of CYP51 inhibitors targeting
Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives, ChemBioChem, 2014, 15, 1111-1120
13. Jun Yong Choi, Claudia M. Calvet, Debora F. Vieira, Shamila S. Gunatilleke, Michael D. Cameron, James H. McKerrow, Larissa M. Podust, and
William R. Roush, The R-Configuration of 4-aminopyridyl-based inhibitors of CYP51 confers superior efficacy against Trypanosoma cruzi, ACS
Med. Chem. Lett., 2014, 5, 434-439
14. Jun Yong Choi, Claudia M. Calvet, Shamila S. Gunatilleke, Claudia Ruiz, Michael D. Cameron, James H. McKerrow, Larissa M. Podust, and
William R. Roush, Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-Chagas agents, J. Med.
Chem., 2013, 56, 7651-7668.
15. Mathieu Bibian, Ronald J. Rahaim, Jun Yong Choi, Yoshihiko Noguchi, Stephan Schürer, Weimin Chen, Shima Nakanishi, Konstantin Licht, Laura
H. Rosenberg, Lin Li, Yangbo Feng, Michael D. Cameron, Derek R. Duckett, John L. Cleveland, William R. Roush, Development of highly selective
casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties, Bioorg. Med. Chem. Lett., 2013, 23, 4374-4380.
16. Jun Yong Choi, Mark S. Plummer, Jeremy Starr, Charlene R. Desbonnet, Holly Soutter, Jeanne Chang, J. Richard Miller, Keith Dillman, Alita A.
Miller, and William R. Roush, Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate
Kinase: from Hit to Lead Generation, J. Med. Chem. 2012, 55, 852-870.
17. Younjoo Lee, Jun Yong Choi, Hong Fu, Colin Harvey, Sandeep Ravindran, William R. Roush, John C. Boothroyd, and Chaitan Khosla, Chemistry
and Biology of Macrolide Antiparasitic Agents, J. Med. Chem., 2011, 54(8), 2792-2804.
18. SA Saldanha, C Grimm, BA Mercer, JY Choi, C Allais, WR Roush, S Heller, P Hodder, Campaign to Identify Agonists of Transient Receptor
Potential Channels 3 and 2 (TRPML3 & TRPML2), National Center for Biotechnology Information (US) Bookshelf, 2010-2012; PMID: 24260779.
(MLPCN Probe Report)
19. Lisa M. Ballou, Elzbieta S. Selinger, Jun Yong Choi, Dale G. Drueckhammer, and Richard Z. Lin, Inhibition of mammalian target of rapamycin
signaling by 2-(morpholine-1-yl)pyrimido[2,1-α]isoquinoline-4-one, J. Biol. Chem., 2007, 282(33), 24463-24479.
20. Eun Joo Roh, Deukjoon Kim, Jun Yong Choi, Bon-Su Lee, Chong Ock Lee and Choong Eui Song, Synthesis, biological activity and receptor
based 3D-QSAR study of 3’-N-substituted-3’-N-debenzoylpaclitaxel analogues, Bioorg. Med. Chem., 2002, 10(10), 3135-3143..
21. Jun Yong Choi, Chang Kon Kim, Chan Kyung Kim, and Ikchoon Lee, High level ab initio study of thermal 1,3-sigmatropic shift in CH2=CHCH2X
with X = BH2, NH2, and CH3, The J. Phys. Chem. A, 2002, 106(23), 5709-5715
Manuscripts In preparation
1. Jun Yong Choi, Joanne Doherty, Spencer D. Wood, John Cleveland, William R. Roush, Identification of the inhibitor binding site in
monocarboxylate transporters 1 and 4, 2017 (in preparation)
2. Jun Yong Choi, Yoshihiko Noguchi, Derek Ducket, William R. Roush, Structure guided development of highly specific CK1ε inhibitors, 2017
(in preparation)
PATENTS
1. Thomas D. Bannister, William R. Roush, Jun Yong Choi, Reji N. Nair, Andy S. Tsai, Jitendra K. Mishra, John L. Cleveland, Heterocyclic inhibitors of monocarboxylate transporters (2019), US Patent App. 15545168
2. Thomas D. Bannister, William R. Roush, Jun Yong Choi, Reji N. Nair, Andy S. Tsai, Jitendra K. Mishra, John L. Cleveland, Heterocyclic compounds as inhibitors of monocarboxylate transporters and their preparation (2016), WO 2016118825 A1 20160728
3. William R. Roush, Jun Yong Choi, Larissa Podust, Aminopyridiy-based lead inhibitors targeting Trypanosoma cruzi CYP51. PCT Int. Appl. (2015),
WO 2015048306 A1 20150402.
4. Richard Lin, Dale Drueckhammer, Jun Yong Choi, Lisa Ballou, Inhibitors of mammalian target of rapamycin (mTOR) and methods of treatment
using same, PCT Int. Appl. (2008), WO 2008148074 A2 20081204